This noun denotes ignorance—the state of not knowing, particularly regarding spiritual and moral truth. In 1 Corinthians 15:34, Paul sharply commands the Corinthians to sober up and stop sinning, declaring 'some have ignorance of God'—a devastating indictment in a church. In 1 Peter 2:15, Christians are called to silence the ignorant talk of foolish people through good conduct. The word emphasizes not innocent lack of information but culpable ignorance, the state of not knowing what one should know. It's particularly damning when it concerns knowledge of God—ignorance that has moral consequences.