This verb describes physical or spiritual exhaustion. In Hebrews 12:3, the author urges believers to 'consider him who endured such hostility from sinners, so that you may not grow weary (κάμητε) and lose heart.' The context is perseverance under trial—looking to Jesus prevents the soul-weariness that leads to giving up. James 5:15 shifts to physical illness: 'the prayer of faith will save the one who is sick (τὸν κάμνοντα),' where the participle describes someone worn down by sickness. The word thus spans from labor-induced fatigue to the enervation of disease, always implying a depletion that needs restoration.