This adverb means 'on the whole,' 'entirely,' or 'at all,' depending on context. In Acts 4:18, the Sanhedrin commands Peter and John 'not to speak or teach at all (katholou) in the name of Jesus.' The term emphasizes totality—a comprehensive ban rather than limited restriction. The council attempted an absolute prohibition on Christian proclamation, which the apostles immediately rejected: 'We cannot but speak of what we have seen and heard' (4:20). Katholou marks the collision between religious authority and prophetic commission.