This adjective means "unmixed," "undiluted," or "pure"—especially applied to wine served neat without the customary addition of water. Classical Greeks typically diluted wine with water; unmixed wine was considered barbaric and dangerously strong. John uses it in Revelation 14:10 in the terrifying judgment oracle: drinking "the wine of God's wrath, poured unmixed into the cup of His anger." The term emphasizes the full-strength, undiluted fury of divine judgment—no mercy mixed in, no mitigation of wrath's intensity. The image of neat wine represents concentrated, untempered judgment in all its fearsome potency.