This verb means to despise, disregard, or treat with contempt. Paul uses it in Titus 2:15 to tell Titus: 'Let no one disregard you' (μηδείς σου περιφρονείτω). The term conveys looking down on or treating as worthless. Paul's command encourages Titus to teach with authority so that his youth or position would not be despised. Classical usage included the sense of thinking around or about, but typically it meant to despise.