This adverb means "out of season," "at an unsuitable time," or "when inconvenient." Classical usage opposed it to "in season" (eukairos), denoting untimely or inopportune moments. Paul uses it in 2 Timothy 4:2 charging Timothy to "preach the word, be ready in season and out of season." The phrase emphasizes faithful ministry regardless of favorable or unfavorable circumstances—whether convenient or inconvenient, whether the audience is receptive or hostile, whether cultural conditions support or oppose the message. The minister's readiness must transcend timing, persisting through both opportune and inopportune seasons.