This adjective describes what is not subject to repentance or regret, hence irrevocable. Paul uses it in Romans 11:29 to declare that τὰ χαρίσματα καὶ ἡ κλῆσις τοῦ θεοῦ ἀμεταμέλητα—God's gifts and calling are irrevocable, assuring Israel's ultimate place in God's plan despite current unbelief. In 2 Corinthians 7:10, godly grief produces μετάνοιαν εἰς σωτηρίαν ἀμεταμέλητον—repentance leading to salvation without regret, contrasting with worldly grief that produces death. The first passage emphasizes God's unchanging commitment; the second, the enduring value of true repentance.